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30 thg 1, 2025 · Tau, Incorporated. A library of tau mutants generated by alanine substitution (red residues, left), was transduced into biosensor cell lines containing pre-existing tau fibril strains. …
11 thg 4, 2024 · An antibody to p-Tau217 reduced tangles and neurodegeneration in mice. Their memory and coordination improved. That antibody, and another against N-terminal tau, …
The Dominantly Inherited Alzheimer Network has been at the vanguard of AD immunotherapy development, launching the first secondary and primary prevention trials, as well as the first …
23 thg 2, 2025 · In an autopsy-confirmed cohort, they found that plasma p-Tau217 flagged the presence of amyloid and tau pathology with high accuracy in people with frontotemporal …
25 thg 11, 2024 · Background LY3954068 is a small interfering RNA (siRNA) that targets expression of the microtubule-associated binding protein tau. No information is available about …
12 thg 9, 2024 · A big tau variant is found in tangle-resistant brain regions such as the cerebellum. This isoform degrades quickly and resists phosphorylation and aggregation. In AD patients, big …
18 thg 2, 2025 · Detecting toxic forms of tau before they weave into dense thickets of tangles could pave the way for earlier diagnosis and treatment of tauopathies, including Alzheimer’s …
Tau pathology is widely considered to be downstream of Aβ pathology and is more closely linked to cognitive deficits in Alzheimer's disease. Mutations in the tau gene cause frontotemporal …
In both wild-type C57BL/6 and P301L mutant tau transgenic mice, a three-month regimen of subcutaneous ACI-35 injection rapidly generated high titers of polyclonal IgG antibodies …
11 thg 7, 2025 · With T cells sidelined in these CD8 knockouts, tau pathology went on the offensive. By 30 weeks of age, phospho-tau had spread deeper into the brain than in CD8 …
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